Publications
Discovery of activity-dependent principle underlying synaptic density regulation
Properties of synaptic transmission at single hippocampal synaptic boutons
Liu and Tsien, Nature, 1995
Importance of NR2B-NMDAR in synaptic plasticity and memory is elucidated from transgenic “Doogie” mice
Genetic enhancement of learning and memory in mice
Tang et al., Nature, 1999
Neuronal intracellular Mg2+ identified as a 2nd messenger controlling synaptic plasticity and density
Enhancement of Synaptic Plasticity through Chronically Reduced Ca2+ Flux during Uncorrelated Activity
Slutsky et al. Neuron, 2004
Enhancement of Learning and Memory by Elevating Brain Magnesium
Slutsky et al. Neuron, 2010
Regulation of density of functional presynaptic terminals by local energy supply
Zhou and Liu. Mol Brain, 2015
L-TAMS identified as drug candidate that increases structural / functional synapse density and promotes neurogenesis
Enhanced learning and memory in young and aged rats
Slutsky et al. Neuron, 2010
Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model
Li et al., Mol Brain, 2014
Increased NR2B-NMDAR pathway in rats
Slutsky et al. Neuron, 2010
Abumaria et al. J Neurosci, 2011
Facilitated removal of fear memory and reduced anxiety
Abumaria et al. J Neurosci, 2011
Abumaria et al., Behav pharma, 2013
Facilitated rejuvenation of the adult visual cortex, providing a new avenue to develop clinical therapies for adult amblyopia
Liu et al., Mol brain, 2015
MOA is mediated by mitochondrial energy production enhancement and movement of Ca++ sensitive proteins to terminals
Zhou et al., Mol brain, 2015
L-threonate is critical for mechanism of action
Sun et al., Neuropharmacology, 2016
Positive results from L-TAMS in human trial in MCI patients (double-blind placebo-controlled)
Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
Liu et al., Journal of Alzheimer’s Disease, 2015
Positive preliminary clinical trial results for L-TAMS tested in mild-moderate AD patients
An 8-week open label trial of L-Threonic Acid Magnesium Salt in patients with mild to moderate dementia
Wroolie, et al, Personalized Med Psych, 2017