Identification of novel signaling pathway for regulating synaptic function and plasticity

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After 20 years of studying regulation of synaptic density and function, we were the first to identify intracellular magnesium as a critical second messenger controlling synaptic 

function and plasticity. 

Discovery of compound to promote synaptogenesis and enhance synaptic function

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Through molecular screening, we identified a novel compound that can selectively elevate intracellular magnesium at the synaptic terminal. In vivo, this compound increases synaptic density, function, and plasticity, and improves learning and memory.