Identification of novel signaling pathway for regulating synaptic function and plasticity
After 20 years of studying regulation of synaptic density and function, we were the first to identify intracellular magnesium as a critical second messenger controlling synaptic
function and plasticity.
Discovery of compound to promote synaptogenesis and enhance synaptic function
Through molecular screening, we identified a novel compound that can selectively elevate intracellular magnesium at the synaptic terminal. In vivo, this compound increases synaptic density, function, and plasticity, and improves learning and memory.